https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The role of Ca²⁺-calmodulin stimulated protein kinase II in ischaemic stroke - a potential target for neuroprotective therapies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34507 2+ -calmodulin stimulated protein kinase II (CaMKII) is a major mediator of ischaemia-induced cell death and suggest that CaMKII would be a good target for neuroprotective therapies in acute treatment of stroke. However, as CaMKII regulates many cellular processes in many tissues any clinical treatment involving the inhibition of CaMKII would need to be able to specifically target the functions of ischaemia-activated CaMKII. In this review we summarise new developments in our understanding of the molecular mechanisms involved in ischaemia-induced CaMKII-mediated cell death that have identified ways in which such specificity of CaMKII inhibition after stroke could be achieved. We also review the mechanisms and phases of tissue damage in ischaemic stroke to identify where and when CaMKII-mediated mechanisms may be involved.]]> Wed 20 Mar 2019 10:25:57 AEDT ]]> Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10824 Wed 11 Apr 2018 16:58:46 AEST ]]> Protein phosphatases 1 and 2A transiently associate with myosin during the peak rate of secretion from mast cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1380 Wed 11 Apr 2018 15:54:32 AEST ]]> Machine learning approach to predict protein phosphorylation sites by incorporating evolutionary information https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16208 Wed 11 Apr 2018 13:33:56 AEST ]]> Controlling the cell cycle: the role of calcium/calmodulin-stimulated protein kinases I and II https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17044 2+ and calmodulin (CaM) as regulators of the cell cycle. Ca²⁺/CaM-stimulated proteins, including the family of multifunctional Ca²⁺/CaM-stimulated protein kinases (CaMK), have also been identified as mediators of cell cycle progression. CaMKII is the best-characterized member of this family, and is regulated by multi-site phosphorylation and targeting. Using pharmacological inhibitors that were believed to be specific for CaMKII , CaMKII has been implicated in every phase of the cell cycle. However, these ‘specific’ inhibitors also produce effects on other CaMKs. These additional effects are usually ignored, and the effects of the inhibitors are normally attributed to CaMKII without further investigation. Using new specific molecular techniques, it has become clear that CaMKI is an important regulator of G₁, whereas CaMKII is essential for regulating G₂/M and the metaphase-anaphase transition. If the mechanisms controlling these events can be fully elucidated, new targets for controlling proliferative diseases may be identified.]]> Wed 11 Apr 2018 11:04:43 AEST ]]> Regulation of CaMKII in vivo: the importance of targeting and the intracellular microenvironment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7995 Wed 11 Apr 2018 09:42:48 AEST ]]> Calcium/Calmodulin-Stimulated Protein Kinase II (CaMKII): Different Functional Outcomes from Activation, Depending on the Cellular Microenvironment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53626 Tue 12 Dec 2023 15:26:24 AEDT ]]> CaMKII kinase activity, targeting and control of cellular functions: effect of single and double phosphorylation of CaMKIIα https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16963 Thu 30 Mar 2023 15:52:22 AEDT ]]> αCaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13748 Sat 24 Mar 2018 10:39:18 AEDT ]]> Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1956 Sat 24 Mar 2018 08:33:17 AEDT ]]> Mast cell function: regulation of degranulation by serine/threonine phosphatases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1293 Sat 24 Mar 2018 08:32:46 AEDT ]]> Autonomous activity and autophosphorylation of CAMPK-II in rat hippocampal slices: effects of tissue preparation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1080 Sat 24 Mar 2018 08:32:09 AEDT ]]> Lead-stimulated p38MAPK-dependent Hsp27 phosphorylation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1407 Sat 24 Mar 2018 08:28:15 AEDT ]]> Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1805 Sat 24 Mar 2018 08:27:31 AEDT ]]> Dephosphorylation of CaMKII at T253 controls the metaphase-anaphase transition https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19054 Sat 24 Mar 2018 08:05:15 AEDT ]]> Biochemical, behavioural and electrophysiological investigations of brain maturation in chickens https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4741 Sat 24 Mar 2018 07:21:10 AEDT ]]> Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3185 Sat 24 Mar 2018 07:18:09 AEDT ]]>